HISTOPATHOLOGY & ENERGY
Tixel transfers energy to skin directly by conduction, the most efficient energy transfer method.
Tixel creates a spherical thermal effect yet it employs much less energy sparing the skin from excessive
heat, carbonization, pain, smoke or smell.
SKIN TEMPERATURE & PAIN
Tixel’s low treatment pain can be explained by the temperature profile in the skin. The temperature on the surface of the skin is 400°C. However, it drops to 50°C at a depth of 100µm.
Pain nociceptors in the skin are located in the deeper epidermis (about 50µm depth). Therefore, pain levels with Tixel are relatively low compared to ablative laser or RF devices in which temperature at deep layers is much higher.
In addition, pain receptors are extremely sensitive to temperature change rate over time. CO2 laser for example generates heat at an extremely fast pathway. Harris et al have shown that CO2 laser heating to 400°C takes about 200ns while the Tixel heating effect is slower by at least 1 magnitude of order.
Permeability of human skin to 5-ALA has been studied by Dr. Christine Dierickx. Results show that Tixel treated skin exhibits 40% greater permeability than non treated control.
The Novoxel devices’ intended use does not currently include tissue permeability enhancement